Artificial Intelligence: AI-Powered ZFDesign Enables Gene Therapy By Manipulation Of Zinc Fingers
The tool has been developed by researchers at NYU Grossman School of Medicine and the University of Toronto.
An AI program, dubbed ZFDesign, has been developed by researchers at NYU and the University of Toronto that allows for the simple production of customizable zinc finger proteins to treat diseases by turning genes on and off.
The tool promises to speed up the development of gene therapies on a large scale, and can be used to treat illnesses such as cystic fibrosis, Tay-Sachs disease, and sickle cell anemia by editing errors in the order of DNA letters. (NEWS-Medical)
The technology, called ZFDesign, uses AI to model and design interactions between zinc fingers and DNA, overcoming the obstacle of designing artificial zinc fingers for specific tasks.
The model is based on data generated by the screen of nearly 50 billion possible zinc finger-DNA interactions in the researchers’ labs.
A report on the tool was published on January 26 in the journal Nature Biotechnology.
“Our program can identify the right grouping of zinc fingers for any modification, making this type of gene editing faster than ever before,” said David Ichikawa, PhD, study lead author, former graduate student at NYU Langone Health.
“By speeding up zinc-finger design coupled with their smaller size, our system paves the way for using these proteins to control multiple genes at the same time,” says study senior author Marcus Noyes, PhD. “In the future, this approach may help correct diseases that have multiple genetic causes, such as heart disease, obesity, and many cases of autism.”
Related Story: Atomic AI Closes $35M Series ‘A’ For RNA Drug Discovery
Image Credit: Wikimedia
Latest Alternative Investment News
Pluto, a prominent provider of financial corporate spend management solutions in the UAE, has forged a strategic alliance with Mastercard (NYSE: MA), the global technology giant in the payments sector….
Alternative Investments/Real Estate: Alternative Investing Platform Yieldstreet Acquires Real-Estate Focused Cadre
Yieldstreet, a prominent private market investment platform, has officially announced its acquisition of Cadre, an online real estate-focused investment platform catering to institutional and high net worth investors. This strategic…
Ursa Major Technologies recently closed its Series D and D-1 funding rounds, securing a substantial $138 million investment led by Explorer 1 Fund and Eclipse, with participation from RTX Ventures,…
Artificial Intelligence: Saudi Venture Fund Forced To Sell Shares In Altman-Backed Chip Startup Rain AI
The Biden administration has compelled Saudi Aramco (TADAWUL: 2222)-backed venture capital firm, Prosperity7, to divest its shares from Rain Neuromorphics, a Silicon Valley AI chip startup supported by Sam Altman,…